ACAN, HA, and perineuronal nets: context and the G1 HA binding unit

Notes

Aggrecan immobilizes to perineuronal nets through hyaluronan-dependent and hyaluronan-independent binding activities Received for publication, December 10, 2024, and in revised form, March 26, 2025 Published, Papers in Press, April 22, 2025, https://doi.org/10.1016/j.jbc.2025.108525 Matthew Y. Otsuka1, Leslie B. Essel1 , Ashis Sinha2, Gabrielle Nickerson2, Seth M. Mejia2, Ashley Edge1, Russell T. Matthews2,‡, *, and Samuel Bouyain1,‡, * From the 1Division of Biological and Biomedical Systems, School of Science and Engineering, University of Missouri-Kansas City, Kansas City, Missouri, USA; 2Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York, USA Reviewed by members of the JBC Editorial Board. Edited by Roger Colbran Aggrecan (ACAN) is a large, secreted chondroitin sulfate proteoglycan that includes three globular regions named G1, G2, G3, and is decorated with multiple glycosaminoglycan at- tachments between its G2 and G3 domains. The N-terminal G1 region interacts with the glycosaminoglycan hyaluronan (HA), which is an essential component of the vertebrate extracellular matrix. In the central nervous system, ACAN ...