SLE Pathophysiology and Diagnosis

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Pathophysiology of Systemic Lupus Erythematosus Integrated Drugs and Diseases II: Rheumatology PHR 937-001 Nicole Miracle, PharmD, MPH, CSP Pharmacy Education and Competency Coordinator UK Specialty Pharmacy and Infusion Services Objectives Describe the pathophysiology of systemic lupus erythematosus (SLE) Discuss diagnostic tools and laboratory tests that lead to a SLE diagnosis Systemic Lupus Erythematosus (SLE) 95% Overall survival at 5 years Affects women more commonly than men Non-white patients have earlier onset of disease, greater severity, and higher mortality Complex autoimmune disease associated with autoantibody production that affects multiple organ systems Predisposing Factors Genetics • 20 times more likely to be affected if 1st degree relative has SLE • HLA-DR2 and HLA-DR3 • Smoking • UV light • Viruses • Medications • Air pollution • Heavy metals • Asbestos Environment Other • Diet • Obesity • Gut microbiota • Hormones Pathophysiology Predisposing Factors Abnormal Immune Response Autoantibody Production Ab-complex formation Ab-complex deposition Inflammation Damage Multi-Organ Failure Pathophysiology. 1 Predisposing Factors GENES High hazard ratios (≥6): Deficienci...