DNA Replication, Transcription, and Translation Overview

Notes

MEHLMANMEDICAL.COM MEHLMANMEDICAL.COM 2 YouTube @mehlmanmedical Instagram @mehlman_medical MEHLMANMEDICAL.COM MEHLMANMEDICAL.COM 3 HY Biochemistry The purpose of this document is not to be a 600-page, long-winded textbook discussing every detail dating back to your high school bio days. The idea is to strike a balance between sufficient detail while staying as concise and HY as possible for USMLE (i.e., I’m aware some students want me to just cut to the chase with HY factoids; others want more in depth discussion of every mechanism). I will also make a separate doc specifically addressing more of the pedantic genetics stuff. Relax. - Student question showed DNA being replicated and they pointed to enzyme at replication fork; - Question asks what is acted upon by DNA ligase to form a DNA sequence that aligns complimentary with the leading strand in DNA synthesis? à answer = Okazaki fragments; the lagging strand in DNA synthesis is composed of Okazaki fragments that are synthesized discontinuously and then amalgamated using DNA ligase. HY DNA replication enzymes for USMLE Enzyme HY points Topoisomerase - Causes nicks in DNA; allows for relief of strand tension; prevents - Fluoro...