Cisplatin

Notes

Cisplatin Pathophysiology: Binds to DNA → cross-links strands → prevents replication → cell death (apoptosis). Works on rapidly dividing cells. Side/adverse effects: N/V, nephrotoxity, ototoxicity, myelosuppression Therapeutic uses: testicular, ovarian, bladder and lung cancer Complications: peripheral neuropathy, renal impairment and ototoxicity Contraindications: renal and hearing impairments Nursing considerations: Assess renal function before and during treatment Monitor fluid balance and electrolyte levels Avoid nephrotoxic drugs, report hearing loss and numbness Administer antiemetics as prescribed Initiate IV fluid before and after medication to prevent kidney damage Zidovudine (AZT) Pathophysiology: Reduces HIV manifestations by inhibiting DNA synthesis and viral replication; HIV treatment and prevention (reduces mother-to-child transmission) Therapeutic uses: First line ART to treat HIV infection for short term care Complications: Suppressions bone marrow, lactic acidosis, n/v, diarrhea and hepatomegaly, myopathy SIde/Adverse effects: Anemia, neutropenia, lactic acidosis, headache, diarrhea, N/V Contraindications: It’s okay if pregnant women take this medication Nursing Co...