Immunity: Innate and Adaptive Defense

Notes

The Concept of Immunity ●Ancient people and Immunity ●Your body’s defense system can be separated into two integrated systems. ●1) Nonspecific or innate immunity mechanisms ●2) Specific immunity mechanisms ●8/19/2022 ●5 Just a Few Important People ●Edward Jenner - 1796 ●Small Pox Vaccine ●Late 1800’s ●Robert Koch-1st Nobel in Medicine ●Germ Theory of Disease ●What did Koch develop as the basis for the GTD? ●Louis Pasteur ●Chicken Cholera ●Rabies Vaccine ●8/20/2022 ●6 8/20/2022 7 A few more… ●Emil von Behring and Shibasaburo Kitasato- 1890 ●Discovered and coined the term antibodies (Ab) ●Ab’s are glycoproteins produced by B cells that interact specifically with antigens(Ag). ●Ag’s are anything that interacts with Ab. ●Elie Metchnikoff ●Studied macrophages and innate immunity. Molecular Biology 1940-1960 ●Chargaff- A=T, G=C ●Watson and Crick- double helix ●Griffith and Avery- bacterial transformation ●Hershey and Chase-Waring blender expt w phage ●Meselsohn and Stahl-Replication is semiconservative 8/20/2022 8 8/20/2022 9 Nobel Prizes in Immunology ●Each year the Nobel Prize is awarded for outstanding contributions in the fields of Physics, Chemistry, Physiology or Medicine, Economic...