TE Strateg

Apuntes

TE Strategies 1. Implanted scaffolds with cells and growth factors (Traditional TE) Create a scaffold seeded with cells (SCs or patient-derived) and infused with growth factors to be implanted into the body to induce tissue regeneration. 2. In situ tissue regeneration using bioactive biomaterials Instead of implanting a pre-formed structure with cells, here we use bioactive biomaterials to interact with the body’s own cells to stimulate self-regeneration: • There’s no need to add cells or growth factors, and the materials can be injectable (e.g. hydrogels). Key Elements 1. Cells They are the building blocks of a new tissue. Types: • Stem cells → MSCs → High proliferation and capacity to produce bone, cartilage, and adipose tissue → Sources: bone marrow and adipose tissue 2. Scaffolds Provide a 3D structure for cells to: • Adhere • Proliferate • Migrate • Organize into functional tissue Properties: • Biocompatible and biodegradable • High porosity and surface area • Mimics the ECM mechanically and chemically • They use both natural (collagen, gelatin) and synthetic (PLGA, PCL) materials 3. Biomaterials The substance scaffolds are made from. They are engineered t...