Front matter and early background on MS and VLA-4

Apuntes

MINISTÉRIO DA SAÚDE FUNDAÇÃO OSWALDO CRUZ INSTITUTO OSWALDO CRUZ Doutorado em Biologia Computacional e de Sistemas ANTI-VLA-4 ANTIBODIES FOR MULTIPLE SCLEROSIS TREATMENT: RATIONAL DESIGN AND STUDY OF THEIR MECHANISMS OF ACTION BY HIGH-CONTENT CELL IMAGING BEATRIZ CHAVES Rio de Janeiro July 2023 2 INSTITUTO OSWALDO CRUZ Programa de Pós-Graduação em Biologia Computacional e de Sistemas Beatriz Chaves Anti-VLA-4 antibodies for multiple sclerosis treatment: rational design and study of their mechanisms of action by high-content cell imaging Thesis presented to Oswaldo Cruz Institute as part of the requirements to obtain the title of Doctor in Computational and System Biology Supervisors: João Hermínio Martins da Silva, PhD Marco Alberto Medeiros, PhD Vinicius Cotta-de-Almeida, PhD Loïc Dupré, PhD RIO DE JANEIRO July 2023 3 INSTITUTO OSWALDO CRUZ Programa de Pós-Graduação em Biologia Computacional e de Sistemas AUTHOR: BEATRIZ CHAVES Anti-VLA-4 antibodies for multiple sclerosis treatment: rational design and study of their mechanisms of action by high-content cell imaging SUPERVISORS: PhD João Hermínio Martins da Silva PhD Marco Alberto Medeiros PhD Vinicius Cotta-de-Almeida PhD Loïc Du...