Bacterial

Apuntes

Bacterial meningitis is an acute purulent infection of the leptomeninges (pia mater and arachnoid mater) and the subarachnoid space medical emergency, it can progress rapidly to severe neurological damage and death It leads to: Intense infflamatory response in the subarachnoid space Disruption of the bloor-barrier Increased the intracraneal pressure Potential cerebral edema and brain herniation Common bacterial pathogenes Neonates Streptococcus B, e.coli Children and adults Streptococcus pneumonieae, nisseria meningitidis Elderly Streptococcus pneumoniae, listeria monocytogenes Phatophysiolgy Bacterial enter to the blood through: Respiratory tract infections Otitis media Sinusitis Head trauma with skull fractures From the bloodstream Bacteria cross the blood-barrier into the subarachnoid space Inmune response Bacteria --> strong inflammatory response Neutrophils migrate into the CFS Cytokines and others inflammatoru mediators Consequences of inflammation Increased permeability of the blood-brain-barrier Cerebral edema: Vasogenic edema (plasma leakage9 Cytotoxic edema (neuronal injury) Intersticial (CSF accumulation) Increased intracraneal pressure Reduce cerebral perfusion (risk of...