Transcription 1/20/2026, 10:07:35 PM

Apuntes

• Subtopic: Patient Presentation and Clinical Findings A 34-year-old kidney transplant patient treated with cyclosporine presents to the office with nausea and anorexia. The patient underwent transplantation 6 months ago and had been doing well until recently. On examination, his blood pressure is 160/96 mm Hg. There is no tenderness at the site of the transplanted kidney. Serum creatinine is 3.4 mg/dL, and no serum cyclosporine level is markedly increased. A month ago, he had normal blood pressure and normal levels of serum creatinine and cyclosporine. Further questioning reveals that the patient has been taking grapefruit juice daily as part of an attempt to improve his overall health. • Subtopic: Most Likely Mechanism of Current Condition Which of the following mechanisms is most likely responsible for this patient's current condition? A. Alteration of gastric acidity (1%) B. Inhibition of cytochrome P450 enzymes in the gut wall (80%) C. Modification of transmembrane drug transport (2%) D. Pharmacodynamic potentiation (13%) E. Reduction of plasma protein binding (1%) **Correct answer: B. Inhibition of cytochrome P450 enzymes in the gut wall** **Explanation:** ...