Introduction to Neonatal Sepsis: Definitions, Epidemiology and Sepsis in Newborns

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1281337PDI0010.1177/11795565241281337Clinical Medicine Insights: PediatricsRaturi and Chandran review-article2024 Neonatal Sepsis: Aetiology, Pathophysiology, Diagnostic Advances and Management Strategies Adi Raturi1 and Suresh Chandran2,3,4,5 1University of Glasgow School of Medicine, Glasgow, UK. 2Department of Neonatology, KK Women’s and Children’s Hospital, Singapore, Singapore. 3Duke NUS Medical School, Singapore, Singapore. 4Lee Kong Chian School of Medicine, Singapore, Singapore. 5Yong Loo Lin School of Medicine, Singapore, Singapore. Clinical Medicine Insights: Pediatrics Volume 18: 1–11 © The Author(s) 2024 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/11795565241281337 https://doi.org/10.1177/11795565241281337 ABSTRACT: Neonatal sepsis, a bloodstream infection in the first 28 days of life, is a leading cause of morbidity and mortality among infants in both developing and developed countries. Additionally, sepsis is distinguished in neonates by unique pathophysiological and presentational factors relating to its development in immature neonatal immune systems. This review focuses on the current understanding of the mechanics and implications of ne...