Anais Brasileiros de Dermatologia 202511002134 202409002

Apuntes

Anais Brasileiros de Dermatologia 2025;100(1): 202409002 Anais Brasileiros de Dermatologia www.anaisdedermatologia.org.br REVIEW Exploring the reality of exosomes in dermatology  Taciana Dal’Forno-Dini a,∗ , Martina Souilljee Birck b , Marco Rocha c , Edileia Bagatin c a Private Practice, Porto Alegre, RS, Brazil b Department of Dermatology, Hospital Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil c Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil Received 19 July 2024; accepted 2 September 2024 Available online 18 November 2024 KEYWORDS Exosomes; Extracellular vesicles; Dermatology Abstract Exosomes are extracellular nanovesicles secreted by several cells in the human and animal body. Consisting of a lipid membrane and encapsulated proteins, they contain biolog- ically active substances such as proteins, DNA, RNA, transcription factors, and metabolites. Discovered in the 1980s, exosomes play an important role in cell-to-cell communication and immune function. They vary in size, content, and function depending on the cell of origin. Exo- somes have attracted interest in the field of Dermatology due to their potential applications i...