CONAN and imaging-driven classification in nAMD: background and need for standardized terminology

Apuntes

Vol.:(0123456789)1 3 https://doi.org/10.1007/s00417-022-05586-w RETINAL DISORDERS Macular neovascularization lesion type and vision outcomes in neovascular age‑related macular degeneration: post hoc analysis of HARBOR K. Bailey Freund 1,2 · Giovanni Staurenghi 3 · Jesse J. Jung 4,5 · Sandrine A. Zweifel 6,7 · Mariano Cozzi 3 · Lauren Hill 8 · Steven Blotner 8 · Min Tsuboi 8 · Shamika Gune 8 Received: 23 September 2021 / Revised: 20 January 2022 / Accepted: 3 February 2022 © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Abstract Purpose To characterize relationships between Consensus on Neovascular Age-Related Macular Degeneration Nomencla- ture (CONAN) Study Group classifications of macular neovascularization (MNV) and visual responses to ranibizumab in patients with neovascular age-related macular degeneration (nAMD). Methods This was a post hoc analysis of the phase 3 HARBOR trial of ranibizumab in nAMD. Analyses included ranibi- zumab-treated eyes with baseline multimodal imaging data; baseline MNV; subretinal and/or intraretinal fluid at screening, baseline, or week 1; and spectral-domain optical coherence tomography images...