Nine studi

Apuntes

Nine studies reported no significant difference in chronic pain between fixation methods. Three identified a significant reduction with NB2C glue556 or FS409, 560 compared with sutures. One RCT of moderate quality randomized 316 patients to either TisseelÒ/TissucolÒ or 2/0 ProleneÒ sutures and reported a significant reduction in chronic pain at 6 months (defined as VAS [ 3) with FS versus sutures (8.1 vs. 14.8%, p = 0.035).560 A very low- quality RCT of 148 patients randomized to either QuixilÒ FS fixation of lightweight mesh or VicrylÒ suture fixation of a heavyweight mesh found chronic pain at 6-month follow-up (determined by mean VAS scores) was lower in the FS/lightweight mesh group (0 vs. 7.8%, p \ 0.001).409 Two further RCTs, the first comparing suture fixation with self-gripping ProGrip mesh and the second comparing suture fixation with fibrin glue reported no difference in chronic pain.182, 561 Pain within the first week postoperatively Six RCTs reported on pain in the first postoperative week. Three studies noted significantly lower mean VAS scores at one or more assessment times within week one, with FS,409 NB2C glue,555 or self-fixing mesh168 compared with suture fixatio...