BIOCHEMISTRY

Apuntes

BIOCHEMISTRY April 22, 2025 PROTEIN METABOLISM Describe the role of the ubiquitin- proteasome system in protein degradation and how it generates free amino acids. Explain the fate of free amino acids after protein breakdown, including their entry into the amino acid pool. Identify the key biochemical reactions involving amino acids: transamination, deamination, and decarboxylation. Relate amino acid metabolism to energy production, nitrogen elimination (urea cycle), and the synthesis of biologically active molecules. Learning Objectives DEFINITION 3 o Protein metabolism is a key physiological process in all forms of life. o Proteins are converted to amino acids and then catabolised. o The complete hydrolysis of a polypeptide requires mixture of peptidases because individual peptidases do not cleave all peptide bonds. o Both exopeptidases and endopeptidases are required for complete conversion of protein to amino acids DEFINITION 4 o Proteins besides all function and hold the potential to serve as a metabolic fuel source. o Proteins are not stored for later use, so excess proteins must be converted into glucose or triglycerides and used to supply energy or build energy reserves. ...