BASIC PRINCIPLES OF PHARMACOLOGY

Apuntes

BASIC PRINCIPLES OF PHARMACOLOGY PHARMACODYNAMICS PHAR1057 – Text 5 th Edition Pharmacodynamics vs Pharmacokinetics DRUG PHARMACOKINETICS PHARMACODYNAMICS 1. Drug Action (MOA) 2. Drug Effect • Pharmacologic • Non - Pharmacologic 3. Drug Interaction 1. Absorption 2. Distribution 3. Metabolism 4. Excretion • Measurements GENERAL USES OF DRUGS Replacing Body Deficiency (Sem 2 Drug = Insulin) ➢ Drug may be used to replace deficiency in the body such as deficiency of vitamin, hormones and neurotransmitters. Altering with Cell Function (Sem 2 Drugs) ➢ Drugs may increase or decrease cellular activity ➢ Drugs may chemically alter body fluids surrounding cell ➢ This then can change cell functions ➢ Drugs may chemically alter cell membrane enzymes & receptors Ridding the Body of Invading Microbes or Abnormal Cells. (Sem 3) ➢ Drugs may act against microbes to reduce their population in the body (e.g., antibacterial and antiviral agents). ➢ Drugs may kill abnormal cells ➢ Chemotherapy - antineoplastic agents such as the alkylating agents Textbook – Special note regarding terms When reading the textbook please make the following distinction...