Membrane interactions, fusion, and Singer-Nicolson: protein roles and review

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Mota y Ana Rodriguez (2001) Microbes and Infection, 3, 1123-1128 The protein TRAP is marked and the distribution is homogeneous on the membrane, but when the parasite contacts the cell, the protein is concentrated in a capping to penetrate Please, Explain the table Integral proteins mediate Cell-Cell interactions and adhesion (Extracellular Matrix , EM). Family of Integral Proteins 1- Integrins (heterodimer): Protein + Extracellular Matrix 2- Cadherin: Prot. + adhesion 3- Selectins (Ca + ) : adhesion (coagulation) 4- N-CAM (similar to Igs domains) Four examples of types of integral proteins that participate in cell-cell interactions. Membrane fusion Processes Requirements for the fusion of 2 membranes: 1- They recognize each other. (SNARES THEORY) 2- The surfaces of the membranes approach removal of H 2 O from the heads of Lipids. 3- The membranes are disrupted locally to form a continum membrane. 4- Two bilayers are fused to form one. 5- The fusion process is fired at an appropriate time in response to a specific signal. Lipid rafts: This are areas with concentrated recepts Rich in sphingolipids and cholesterol Discussion of paper about Fluid Mosaic Model Answer the following ques...