Review article

Apuntes

Review article T h e n e w e ng l a n d j o u r na l o f m e dic i n e n engl j med 366;24 nejm.org june 14 , 2012 2294 Medical Progress Guillain–Barré Syndrome Nobuhiro Yuki, M.D., Ph.D., and Hans-Peter Hartung, M.D. From the Department of Medicine, Na- tional University of Singapore, Singapore (N.Y.); and the Department of Neurology, Heinrich Heine University, Düsseldorf, Germany (H.-P.H.). Address reprint re- quests to Dr. Yuki at the Department of Medicine, National University of Singa- pore, Unit 09-01, Centre for Translational Medicine, 14 Medical Dr., Singapore 117599, Singapore, or at yuki.research@ gmail.com. This article (10.1056/NEJMra1114525) was updated on June 14, 2012, at NEJM.org. N Engl J Med 2012;366:2294-304. Copyright © 2012 Massachusetts Medical Society. T he Guillain–Barré syndrome, which is characterized by acute areflexic paralysis with albuminocytologic dissociation (i.e., high levels of protein in the cerebrospinal fluid and normal cell counts), was described in 1916. 1 Since poliomyelitis has nearly been eliminated, the Guillain–Barré syndrome is currently the most frequent cause of acute flaccid paralysis worldwide and consti- tut...