Ferroptosis1 mechanisms2 biology3 and role in disease

Apuntes

Ferroptosis: mechanisms, biology, and role in disease Xuejun Jiang 1,* , Brent R. Stockwell 2,* , Marcus Conrad 3,4,* 1 Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 2 Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY 10027, USA 3 Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany 4 Pirogov Russian National Research Medical University, Moscow, Russia Abstract The research field of ferroptosis has been enjoying exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-dependent phospholipid peroxidation, is regulated by multiple cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars, in addition to numerous signaling pathways relevant to disease. Intriguingly, therapy- resistant cancer cells, particularly those of the mesenchymal state and prone to metastasis, are exquisitely vulnerable to ferroptosis. Further, numerous organ injuries and degenerative pathologies are driven by ferroptosis. As such, pha...