Type I collagen in myocardial infarction healing and tissue localization

Anotacoes

A 67-year-old man is found dead in his home. The cause of death is not apparent; he had a long history of hypertension and he had a myocardial infarction a year ago. An autopsy is performed. Gross examination of the heart shows white scarring and enlargement of the left ventricle. Histologic findings from a section of the left ventricle are shown below. The type of collagen seen in the autopsy sample is most likely to be extensively found in which of the following normal body tissues? A. Basement membrane (9%) B. Granulation tissue (35%) C. Hyaline cartilage (18%) D. Nucleus pulposus (2%) E. Tendon (32%) Collagen subtypes Type Locations Associated diseases I Skin, bone, tendons, ligaments, dentin, cornea, blood vessels & scar tissue Osteogenesis imperfecta II Cartilage, vitreous humor & nucleus pulposus Skeletal dysplasias III Skin, lungs, intestines, blood vessels, bone marrow, lymphatics & granulation tissue Vascular Ehlers-Danlos syndrome (Type IV) IV Basement membrane Alport syndrome Time after myocardial infarction Predominant light microscopic changes 0-4 hours • No visible change 4-12 hours • Wavy fibers with narrow, elongated myocytes 12-24 hours • Myocyte hypereosinophilia...